Aromatase

An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.

Also Known As:

CYP19; Androstenedione Aromatase; CYP 19; CYP19 Protein; Cytochrome P450 19; Estrogen Synthase; Estrogen Synthetase; P450AROM; Aromatase, Androstenedione; Cytochrome P 450 CYP19; Protein, CYP19; Cytochrome P-450 CYP19; Cytochrome P-450(AROM)

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Oxidoreductases: 13899
    - Oxygenases: 336
      - Mixed Function Oxygenases: 2207
        Cytochrome P-450 Enzyme System: 5452
        Cytochrome P450 Family 19: 20
        Aromatase: 2880
        Steroid Hydroxylases: 11
        Aromatase: 2880
- Cytochromes: 2210
  - Cytochrome P-450 Enzyme System: 5452
    - Cytochrome P450 Family 19: 20
      - Aromatase: 2880
    - Steroid Hydroxylases: 11
      - Aromatase: 2880
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Hemeproteins: 196
    - Cytochromes: 2210
      - Cytochrome P-450 Enzyme System: 5452
        Cytochrome P450 Family 19: 20
        Aromatase: 2880
        Steroid Hydroxylases: 11
        Aromatase: 2880

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